Calling all Hens

... alien in the airlock

What does it take to be a Little Red Hen?

Aptitude, enthusiasm, and the intelligence to know if something looks useful or just doesn’t seem right. Two of our greatest Little Red Hens had only G.E.D.s so it certainly isn’t book smarts. Hell, I went to college twice and dropped out both times never got a degree and was voted the Smartest Man That Ever Lived (by myself for the past 15 years).

Three hours of video doesn’t get assembled all by itself. Grannie Annie and I spent countless hours working behind the scenes to put together the REAL cause/reason behind the false Opioid Crisis. Grannie had only a G.E.D. but she could hound-dog a trail to its bitter end. I don’t and I can’t do what I do alone.

So I’m axing my old time Hens and anyone who wants to fly around the barnyard to see if we can get an answer for someone who needs it on a topic that is central to what Grannie and I uncovered 4 years ago.

Low Dose Naltrexone is used as a therapy for many conditions. One of them is pain management. But let me spell this out for you and shorten the 3 hour video above into the core idea:
- When opioids contact the receptors on nerve cells it opens them up so that herpes viruses can enter.
- Herpes viruses cause pain in nerves.
- Pain causes the host to seek more opioids.
- More opioids creates more cell permissivity to viruses that lets in more Herpes.
- More Herpes causes more pain.
- More pain causes the host to seek MORE OPIOIDS.
- Lather, Rinse, Repeat.

Someone with a G.E.D. and a Farm Boy could figure this out.

What the hell is wrong with everyone else?

So, the story goes that Naltrexone is used for for alcohol and narcotic addiction. Naltrexone binds to the opioid receptor to replace the action of alcohol and opioids on that binding site. Typically this is called competitive or allosteric inhibition. In this case they are calling it antagonism. See my Stack

Accuracy in Science Language

For my rage against this very thing. Lack of specificity and accurate description and explanation in Science. An Agonist is something that binds to a receptor to make it turn on. An Antagonist is something that binds to a receptor to either block the thing that usually plugs into that hole or turn the receptor function off. They also play loose with language when referring to “blocking” because is is unclear if the blocker

1. Blocks the usual binding agent but still turns the receptor on, or

2. Blocks the usual binding agent and turns the receptor off.

HUGE DIFFERENCE BETWEEN THE TWO.

In #1 you would still feel the ‘high’ but you have just traded the Devil You Know: Booze and Opioids for a surrogate drug for the same feeling. Typical government engineered Bait & Switch.

In #2 you block the drug from getting through but also block any sensation from the receptor because it is not stimulated.

Because I don’t expect folks to do heavy lifting beyond their knowledge or field of interest, I lifted this from the Physicians Desk Reference:
”Naltrexone, an opioid antagonist, is a synthetic congener of oxymorphone with no opioid agonist properties.”

They used all of the Magick Words, and it seems straightforward enough, but since ALL herpes viruses are cancer-causing and we don’t want that receptor site activated to let more Aliens in the Airlock, then I would like additional confirmation from different sources that what they said works exactly that way.

Blocking the sensation from the receptor would make me think it would drive people harder to find a fix to get high.
But what do I know?
Nothing. Which is why I’m axing for some outside help. This is really a simple mathematical or electrical switch kindof question that someone somewhere has to have studied and published on. The biochemistry is complex so I wouldn’t expect most of the Little Red Hens or those who want to do this work to know or even want to know. If I were provided such work I could figure it out, unless of course it was written by total idiots whose sole purpose was to get a grant to write a paper that said nothing. After 23 years and only finding 5 papers that qualified as Real Science both You and I, Dear Reader are in for an uber-brain-reaming.

ANY help on this will be appreciated. NO idea is too small or not useful. Please post your thoughts and findings in the comments because although this is for one person in particular, everyone who sees this Stack can benefit from it.

Thanks